Potassium Nitrate → HCID 67132669, compound

HRID 1518176Notes

Reaction equation

HRID 1518176 reaction equation
[CH3:1][C:2]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])([CH3:10])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[N+:16]([O-])([O-:18])=[O:17].[K+]>OS(O)(=O)=O>[CH3:10][C:2]([NH:11][C:12](=[O:15])[CH2:13][CH3:14])([CH3:1])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([N+:16]([O-:18])=[O:17])=[CH:8][CH:9]=1

Participants

4

Reactant 2

HCID 24434Potassium NitrateHCID 547425HCID 547425, compound

Product 1

HCID 67132669HCID 67132669, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

To H2SO4(20 ml) at 0-10° C. N-(1,1-dimethyl-2-phenyl-ethyl)-propionamide was slowly added. The mixture was stirred until a clear solution was obtained. Then KNO3 (750 mg, 7.42 mmol) was added in portions at 0-5° C. The mixture was stirred at room temperature for 16 h after which it was poured into ice water. The aqueous layer was extracted three times with ethyl acetate. The combined organic layers were washed with NaOH, water and brine, dried over MgSO4, filtered, and the solvent evaporated under reduced pressure to give the product as a brown oil (1 g, 55%).

Workup

  1. customat 0-10° C
  2. customwas obtained
  3. stirringThe mixture was stirred at room temperature for 16 h after which it
  4. extractionThe aqueous layer was extracted three times with ethyl acetate
  5. washThe combined organic layers were washed with NaOH, water and brine
  6. dry with materialdried over MgSO4
  7. filtrationfiltered
  8. customthe solvent evaporated under reduced pressure

Sources & evidence

ORD record
ord-c2bee705e0ae47e7a22bff236b8b7aaa
Source dataset
uspto-grants-2012_07
Patent number
US08232426B2

Reaction notes

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