反应详情

To H2SO4(20 ml) at 0-10° C. N-(1,1-dimethyl-2-phenyl-ethyl)-propionamide was slowly added. The mixture was stirred until a clear solution was obtained. Then KNO3 (750 mg, 7.42 mmol) was added in portions at 0-5° C. The mixture was stirred at room temperature for 16 h after which it was poured into ice water. The aqueous layer was extracted three times with ethyl acetate. The combined organic layers were washed with NaOH, water and brine, dried over MgSO4, filtered, and the solvent evaporated under reduced pressure to give the product as a brown oil (1 g, 55%).

1. customat 0-10° C
2. customwas obtained
3. stirringThe mixture was stirred at room temperature for 16 h after which it
4. extractionThe aqueous layer was extracted three times with ethyl acetate
5. washThe combined organic layers were washed with NaOH, water and brine
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customthe solvent evaporated under reduced pressure