反应详情

温度

0 °C

To a solution of allyl-[2-(4-amino-phenyl)ethyl]-carbamic acid tert-butyl ester (1.86 g, 6.74 mmol) in pyridine (25 ml) at 0° C. was added 4-isopropyl-benzenesulfonyl chloride (1.47 g, 6.74 mmol) and the mixture was stirred at 0° C. for 1 h. After concentration in vacuo the residue was partitioned between ethyl acetate and saturated aqueous NaHCO3. The organic layer was washed with water, dried over MgSO4, filtered and the solvent evaporated under reduced pressure. The residue was purified by column chromatography (n-heptane/ethyl acetate, 2/1) to give the product as a yellow resin (1.35 g, 43.6 mmol).

1. concentrationAfter concentration in vacuo the residue
2. customwas partitioned between ethyl acetate and saturated aqueous NaHCO3
3. washThe organic layer was washed with water
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customthe solvent evaporated under reduced pressure
7. customThe residue was purified by column chromatography (n-heptane/ethyl acetate, 2/1)