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HRID1518290

反应详情

EQUATION

反应方程式

HRID 1518290 的结构方程式

REACTANTS

反应物

2
结构：O=C1CCC(=O)N1Br
HCID67184

1-Bromopyrrolidine-2,5-dione

C4H4BrNO2

结构：CCOC(=O)c1csc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)n1
HCID59447601

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)c1nc(N2CCc3cccc(C(=O)Nc4nc5ccccc5s4)c3C2)sc1Br
HCID59447489

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

To compound 34A in acetonitrile was added 1.05 eq of NBS. The reaction mixture was stirred at rt for 2 hours. The solvent was removed, and the residue was purified by column chromatography on silica gel eluting with 3:2 hexanes/EtOAc to provide the desired product: MS (ESI(+)): 544 (M+H).

WORKUP

后处理

  1. customThe solvent was removed
  2. customthe residue was purified by column chromatography on silica gel eluting with 3:2 hexanes/EtOAc