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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1518295Generated: October 27, 2026

3-(Benzyloxy)benzoic acid → tert-butyl 5-amino-4-cyano-3-(3-hydroxyphenyl)-1H-pyrazole-1-carboxylate

https://huagongshe.com/reaction/1518295

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Benzyloxy)benzoic acidHCID 309226—
Reactanttert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylateHCID 136027725—
Producttert-butyl 5-amino-4-cyano-3-(3-hydroxyphenyl)-1H-pyrazole-1-carboxylateHCID 59447530—

Reaction Steps

Compound 36A was prepared in a similar manner to the synthesis of compound 31F by substituting 4-(benzyloxy)benzoic acid with 3-(benzyloxy)benzoic acid: 1H NMR (DMSO-d6): δ 9.70 (s, 1H), 7.68 (s, 2H), 7.25-7.32 (m, 3H), 6.86-6.89 (m, 1H), 1.60 (s, 9H). MS (ESI(+)): m/z 322 (M+Na).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08232273B2
Source datasetuspto-grants-2012_07
ORD IDord-c7dec6bb0bdc4f3992a07ce39ab2aaec
Source noteuspto-grants-2012_07