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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1518298생성일: 2026년 10월 27일

2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylic acid → HCID 178509383, 화합물

https://huagongshe.com/reaction/1518298

반응식

참여 물질

역할이름HCID투입량
반응물2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylic acidHCID 46837054—
반응물ethyl 5-(3-(3-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)prop-1-ynyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylateHCID 86761595—
생성물HCID 178509383HCID 178509383—

반응 단계

Title compound 36 was prepared in a similar manner to the synthesis of compound 34 by substituting compound 34D with compound 36C in step 5 of Example 34: 1H NMR (DMSO-d6): δ 8.03 (d, J=7.93 Hz, 1H), 7.79 (d, J=7.93 Hz, 1H), 7.66-7.68 (m, 1H), 7.35-7.48 (m, 8H), 5.08 (s, 2H), 4.91 (s, 2H), 3.70-3.73 (m, 2H), 3.46-3.49 (m, 2H), 3.05-3.07 (m, 2H). MS (ESI(+)): m/z 670 (M−H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08232273B2
출처 데이터셋uspto-grants-2012_07
ORD IDord-c014114f4dda4c0a97b859b9cb231f9d
출처 메모uspto-grants-2012_07