HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylic acid → HCID 178509392, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(4-(hydroxymethyl)phenyl)thiazole-4-carboxylic acid | HCID 46837054 | — |
| Reactant | ethyl 5-(3-(4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)prop-1-ynyl)-2-(8-(benzo[d]thiazol-2-yl(tert-butoxycarbonyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate | HCID 86644323 | — |
| Product | HCID 178509392 | HCID 178509392 | — |
Reaction Steps
The title compound 40 was prepared in a similar manner to the synthesis of compound 34 by substituting compound 34D with compound 40A: 1H NMR (DMSO-d6): δ 8.03 (d, J=7.98 Hz, 1H), 7.60-7.80 (m, 5H), 7.34-7.50 (m, 6H), 7.32-7.49 (m, 6H), 7.12 (d, J=8.9 Hz, 2H), 5.10 (s, 2H), 4.91 (s, 2H), 3.73-3.75 (m, 2H), 3.05-3.07 (m, 2H). MS (ESI(+)): m/z 673 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232273B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-f506c34fb8234bfcad3fa958619bf1a9 |
| Source note | uspto-grants-2012_07 |