ethyl 5-(4-((4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate → HCID 178499109, compound

Participants

Reaction Steps

Compound 45E was prepared in a similar manner to the synthesis of compound 35A by substituting compound 34D with compound 45D in step 1 of Example 35: 1H NMR (DMSO-d6): δ 8.24 (dd, J=7.52, 1.38 Hz, 1H), 7.94 (d, J=7.67 Hz, 1H), 7.70 (d, J=7.98 Hz, 1H), 7.67 (s, 2H), 7.53-7.57 (m, 1H), 7.34-7.43 (m, 3H), 7.10-7.14 (m, 2H), 6.00 (s, 2H), 5.57 (s, 2H), 5.17 (s, 2H), 3.81 (s, 3H), 3.76 (t, J=5.98 Hz, 2H), 3.66-3.70 (m, 2H), 3.04 (t, J=6.14 Hz, 2H), 0.85-0.89 (m, 2H), −0.20 (s, 9H). MS (ESI(+)): m/z 892 (M+NH4—H2O).

Provenance & Evidence