HRID1518325

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID15219960

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1nc(N2CCc3cccc(C(=O)N(COCC[Si](C)(C)C)c4nc5ccccc5s4)c3C2)sc1CCCOc1ccc(-c2csc(N)c2C#N)cc1

HCID59447498

未命名化合物

PROCEDURE

实验过程

Compound 47G was prepared in a similar manner to the synthesis of compound 35A by substituting compound 34B and compound 31F with compound 47F and compound 47C, respectively: MS (ESI(+)): m/z 838 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9540a2846e104d689f8e4feaf0b993fe
来源数据集: uspto-grants-2012_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08232273B2
来源说明: uspto-grants-2012_07

反应 SMILES

NC1N(C(OC(C)(C)C)=O)N=C(C2C=CC(OCC3C=CC(C4SC(N5CCC6C(=C(C(=O)N(C7SC8C=CC=CC=8N=7)COCC[Si](C)(C)C)C=CC=6)C5)=NC=4C(OCC)=O)=CC=3)=CC=2)C=1C#N.NC1N(C(OC(C)(C)C)=O)N=C(C2C=CC(O)=CC=2)C=1C#N.[S:92]1[C:96]2[CH:97]=[CH:98][CH:99]=[CH:100][C:95]=2[N:94]=[C:93]1[N:101]([CH2:127][O:128][CH2:129][CH2:130][Si:131]([CH3:134])([CH3:133])[CH3:132])[C:102]([C:104]1[CH:105]=[CH:106][CH:107]=[C:108]2[C:113]=1[CH2:112][N:111]([C:114]1[S:115][C:116]([CH2:123][CH2:124][CH2:125][OH:126])=[C:117]([C:119]([O:121][CH3:122])=[O:120])[N:118]=1)[CH2:110][CH2:109]2)=[O:103].[NH2:135][C:136]1[S:137][CH:138]=[C:139]([C:143]2[CH:148]=[CH:147][C:146](O)=[CH:145][CH:144]=2)[C:140]=1[C:141]#[N:142]>>[NH2:135][C:136]1[S:137][CH:138]=[C:139]([C:143]2[CH:148]=[CH:147][C:146]([O:126][CH2:125][CH2:124][CH2:123][C:116]3[S:115][C:114]([N:111]4[CH2:110][CH2:109][C:108]5[C:113](=[C:104]([C:102](=[O:103])[N:101]([C:93]6[S:92][C:96]7[CH:97]=[CH:98][CH:99]=[CH:100][C:95]=7[N:94]=6)[CH2:127][O:128][CH2:129][CH2:130][Si:131]([CH3:134])([CH3:133])[CH3:132])[CH:105]=[CH:106][CH:107]=5)[CH2:112]4)=[N:118][C:117]=3[C:119]([O:121][CH3:122])=[O:120])=[CH:145][CH:144]=2)[C:140]=1[C:141]#[N:142]