2-[8-(Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-5-{3-[4-(4-cyano-thiophen-3-yl)-phenoxy]-propyl]-thiazole-4-carboxylic acid → 2-[8-(Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-5-{3-[4-(3-cyano-pyridin-2-yl)-phenoxy]-propyl}-thiazole-4-carboxylic acid

Participants

Reaction Steps

Title compound 56 was prepared in a similar manner to the synthesis of compound 51 by substituting compound 51A with compound 56A in step 2 of Example 51: 1H NMR (DMSO-d6): δ 8.86 (dd, J=4.76, 1.69 Hz, 1H), 8.34 (dd, J=7.82, 1.69 Hz, 1H), 8.01 (d, J=7.67 Hz, 1H), 7.82 (d, J=8.9 Hz, 2H), 7.77 (d, J=7.98 Hz, 1H), 7.66 (d, J=7.36 Hz, 1H), 7.32-7.53 (m, 5H), 7.07 (d, J=8.9 Hz, 2H), 4.83 (s, 2H), 4.07 (t, J=6.14 Hz, 2H), 3.70-3.73 (m, 2H), 3.18-3.22 (m, 2H), 3.01-3.03 (m, 2H), 2.00-2.08 (m, 2H). ESI (+)/MS: 673 (M+H)+.

Provenance & Evidence