N,N-Dimethylpropargylamine → HCID 59447599, compound

Participants

Role	Name	HCID	Charge
Reactant	N,N-Dimethylpropargylamine	HCID 81643	—
Reactant	HCID 59447608	HCID 59447608	—
Catalyst	Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)	HCID 24350	—
Catalyst	HCID 178418476	HCID 178418476	—
Solvent	Dimethylformamide	HCID 6228	—
Product	HCID 59447599	HCID 59447599	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

To a mixture of compound 57A (154 mg, 0.593 mmol), N,N-dimethylprop-2-yn-1-amine (0.190 ml, 1.778 mmol), (PPh3)2PdCl2 (62.4 mg, 0.089 mmol), TEA (0.413 ml, 2.96 mmol) in DMF (3 ml) was added copper(I) iodide (11.29 mg, 0.059 mmol). The resulting mixture was heated at 150° C. in a Smith microwave synthesizer for 30 min and purified by flash chromatography to provide the desired compound 57B; LCMS (APCI) m/e 307.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08232273B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-aef2c42fbf064ce5be0c3d1e51859775
Source note	uspto-grants-2012_07