反应详情

A mixture of compound 65A (0.125 g, 0.5 mmol), and propan-2-amine (0.148 g, 2.5 mmol) in ethanol (10 mL) was heated under reflux for 15 hours. The solvent was removed, and the residue was purified by flash column chromatography on silica gel eluting with 1:1 EtOAc/hexanes to give 0.13 g of the title compound: 1H NMR (DMSO-d6): δ 8.50 (s, 1H), 8.28 (s, 1H), 7.87 (d, J=7.46 Hz, 1H), 4.40-4.51 (m, 1H), 1.23 (d, J=6.78 Hz, 6H). ESI (+)/MS: 273 (M−H)+.

1. temperaturewas heated
2. temperatureunder reflux for 15 hours
3. customThe solvent was removed
4. customthe residue was purified by flash column chromatography on silica gel eluting with 1:1 EtOAc/hexanes