2-[8-(Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-5-{3-[4-(4-cyano-thiophen-3-yl)-phenoxy]-propyl]-thiazole-4-carboxylic acid → HCID 59447566, compound

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Reaction Steps

The title compound 70 was prepared in a similar manner to the synthesis of compound 51 by substituting compound 51A with compound 70A: 1H NMR (DMSO-d6): δ 8.39-8.44 (m, 2H), 8.11-8.15 (m, 2H), 8.04 (d, J=7.98 Hz, 1H), 7.78-7.84 (m, 2H), 7.68 (d, J=7.36 Hz, 1H), 7.34-7.50 (m, 4H), 6.90 (d, J=8.29 Hz, 1H), 4.79 (s, 2H), 3.69 (d, J=5.98 Hz, 2H), 3.06-3.10 (m, 4H), 3.03 (t, J=5.98 Hz, 2H). ESI (+)/MS: 665 (M+H)+.

Provenance & Evidence