Hydrochloric Acid → 5-(3-(4-(1H-pyrazol-4-yl)phenoxy)propyl)-2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylic acid

Participants

Reaction Steps

Compound 73A (30 mg) in DCM (1 ml) was treated with HCl 2 N in ether (5 ml) for 2 days. The precipitate was collected and dried to give the title compound 73: 1H NMR (400 MHz, DMSO-D6) δ ppm 8.09 (2H, s), 8.02 (1H, d), 7.79 (1H, d), 7.68 (1H, d), 7.51 (2H, d), 7.44-7.48 (2H, m), 7.33-7.42 (2H, m), 6.91 (2H, d), 4.87 (2H, s), 3.99 (2H, t), 3.75 (2H, t), 3.19 (2H, t), 3.04 (2H, t); LCMS (APCI) m/e 637 (M+H).

Provenance & Evidence