1-Pyrrolidinepropanamine → 7-bromo-N-(3-(pyrrolidin-1-yl)propyl)thieno[3,2-d]pyrimidin-4-amine

HRID 1518362Notes

Reaction equation

HRID 1518362 reaction equation
[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([NH:11][CH:12]([CH3:14])C)[C:5]=2[S:4][CH:3]=1.[N:15]1([CH2:20]CCN)[CH2:19][CH2:18][CH2:17][CH2:16]1>>[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([NH:11][CH2:12][CH2:14][CH2:20][N:15]3[CH2:19][CH2:18][CH2:17][CH2:16]3)[C:5]=2[S:4][CH:3]=1

Participants

3

Reactant 2

HCID 316701-PyrrolidinepropanamineHCID 594476427-bromo-N-isopropylthieno[3,2-d]pyrimidin-4-amine

Product 1

HCID 594476567-bromo-N-(3-(pyrrolidin-1-yl)propyl)thieno[3,2-d]pyrimidin-4-amine

Procedure

Compound 78A was prepared in a similar manner to the synthesis of compound 69A by substituting propan-2-amine with 3-(pyrrolidin-1-yl)propan-1-amine: APCI (+)LC/MS: 342 (M+H)+.

Sources & evidence

ORD record
ord-de9251ca1d5d487db689120559ef544e
Source dataset
uspto-grants-2012_07
Patent number
US08232273B2

Reaction notes

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