HuagongsheHuagongshe Chemistry Print Report · For research reference only
Monobenzone → 4-(2-(4-(Benzyloxy)phenoxy)ethyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Monobenzone | HCID 7638 | — |
| Reactant | 2-Morpholinoethanol | HCID 61163 | — |
| Reactant | ethyl 5-(4-((4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate | HCID 59447596 | — |
| Reactant | tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate | HCID 136027725 | — |
| Product | 4-(2-(4-(Benzyloxy)phenoxy)ethyl)morpholine | HCID 2296950 | — |
Reaction Steps
Compound 88A was prepared in a similar manner to the synthesis of compound 35A by substituting compound 34B and compound 31F with 2-morpholinoethanol and 4-(benzyloxy)phenol, respectively: ESI (+)LC/MS: 314 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232273B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-f9da4b10df074e2293322b095ff813e3 |
| Source note | uspto-grants-2012_07 |