反应详情

Compound 90B was prepared in a similar manner to the synthesis of compound 34D by substituting compound 34C and 4-(hydroxymethyl)phenylboronic acid with compound 90A and 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol, respectively: 1H NMR (DMSO-d6): δ 9.56 (s, 1H), 8.29 (d, J=2.76 Hz, 1H), 7.83 (d, J=8.59 Hz, 2H), 7.74 (d, J=8.59 Hz, 2H), 7.41 (dd, J=8.59, 2.76 Hz, 2H), 6.82 (d, J=8.29 Hz, 2H), 4.14 (t, J=5.68 Hz, 2H), 2.64 (t, J=5.68 Hz, 2H), 2.22 (s, 6H). ESI (+)/MS: 258 (M+H)+.