Hydrochloric Acid → HCID 178450837, compound

Participants

Reaction Conditions

Reaction Steps

Compound 94D (1.47 g) was dissolved in THF (30 mL). To this solution was added 5% HCl (10 mL). The reaction mixture was heated at 48° C. for 90 min. After cooling to room temperature, the reaction mixture was quenched with sat. NaHCO3 solution until no more CO2 was released. The solution was concentrated under vacuum. The residue was re-dissolved in EtOAc, and treated with water (100 mL). The organic layer was separated, and the aqueous layer was extracted with additional EtOAc (three times). The combined organic layers were washed with brine, dried (MgSO4), filtered and concentrated under vacuum. The residue was purified with flash column chromatography on silica gel eluting with 7:3/Hex:EtOAc to give 1.10 g of the title compound 94E (80%): APCI (+)LC/MS: 673 (M+H)+.

Provenance & Evidence