HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(4-Methyl-1-piperazinyl)phenol → tert-butyl 6-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(4-methylpiperazin-1-yl)phenoxy)propyl)picolinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(4-Methyl-1-piperazinyl)phenol | HCID 11622486 | — |
| Reactant | ethyl 5-(4-((4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylate | HCID 59447596 | — |
| Reactant | tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate | HCID 136027725 | — |
| Reactant | HCID 178450838 | HCID 178450838 | — |
| Product | tert-butyl 6-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(4-methylpiperazin-1-yl)phenoxy)propyl)picolinate | HCID 59447636 | — |
Reaction Steps
The title compound 94G was prepared in a similar manner to the synthesis of compound 35A by substituting compound 34D and compound 31F with compound 94F and compound 82A, respectively: ESI (+)LC/MS: 849 (M+H2O—NH4)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232273B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-4081dbce29a242c78e929f79505c22b8 |
| Source note | uspto-grants-2012_07 |