HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 4-(1-Methylpiperidin-4-ylamino)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | 1-Methyl-4-piperidone | HCID 74049 | — |
| Reactant | methyl 2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-((4-phenylpiperazin-1-yl)methyl)thiazole-4-carboxylate | HCID 59447670 | — |
| Reactant | HCID 178499107 | HCID 178499107 | — |
| Product | 4-(1-Methylpiperidin-4-ylamino)phenol | HCID 43742671 | — |
Reaction Steps
The compound 104A was prepared in a similar manner to the synthesis of compound 62A by substituting 1-phenylpiperazine and compound 45C with 4-aminophenol and 1-methylpiperidin-4-one, respectively: ESI (+)/LC/MS: 207 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232273B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-162accf2cfdc405580c12bf184dc97fe |
| Source note | uspto-grants-2012_07 |