化工社化工社 化学情報印刷レポート · 研究参考用
Trifluoroacetic acid → tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(1-methylpiperidin-4-ylamino)phenoxy)propyl)picolinate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4-(1-Methylpiperidin-4-ylamino)phenol | HCID 43742671 | — |
| 反応物 | ethyl 2-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-5-(3-iodopropyl)thiazole-4-carboxylate | HCID 59447467 | — |
| 反応物 | tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-iodopropyl)picolinate | HCID 59447593 | — |
| 生成物 | tert-butyl 6-(8-(benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(1-methylpiperidin-4-ylamino)phenoxy)propyl)picolinate | HCID 59447558 | — |
反応手順
The compound 104B was prepared as a TFA salt in a similar manner to the synthesis of step 2 of Example 51 by substituting compound 51A and compound 2C with compound 104A and compound 96D, respectively: APCI (+)/LC/MS: 733 (M+H)−.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08232273B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-58be109a047940fcb43103287f37d318 |
| 出典メモ | uspto-grants-2012_07 |