6-[8-(Benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-3-{3-[4-(4-methyl-piperazin-1-yl)-phenoxy]-propyl}-pyridine-2-carboxylic acid → 6-(8-(Benzo[d]thiazol-2-ylcarbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)-3-(3-(4-(1-methylpiperidin-4-ylamino)phenoxy)propyl)picolinic acid

Participants

Reaction Steps

The title compound 104 was prepared in a similar manner to the synthesis of compound 94 by substituting compound 94G with compound 104B: 1H NMR (DMSO-d6): δ 12.84 (s, 1H), 9.40 (s, 1H), 8.04 (d, J=7.63 Hz, 1H), 7.79 (d, J=8.24 Hz, 1H), 7.60 (d, J=7.32 Hz, 1H), 7.55 (d, J=8.85 Hz, 1H), 7.34-7.49 (m, 4H), 6.96 (d, J=8.85 Hz, 1H), 6.60-6.79 (m, 1H), 4.92 (s, 2H), 3.81-3.88 (m, 4H), 2.97-3.00 (m, 4H), 2.74-2.80 (m, 4H), 2.10-2.13 (m, 2H), 1.87-1.92 (m, 4H) ESI (+)/MS: 677 (M+H)+.

Provenance & Evidence