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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1518400Generated: November 4, 2026

Monobenzone → 1-(2-(4-(Benzyloxy)phenoxy)ethyl)pyrrolidine

https://huagongshe.com/reaction/1518400

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMonobenzoneHCID 7638—
Reactant1-PyrrolidineethanolHCID 76288—
Reactantethyl 5-(4-((4-(5-amino-1-(tert-butoxycarbonyl)-4-cyano-1H-pyrazol-3-yl)phenoxy)methyl)phenyl)-2-(8-(benzo[d]thiazol-2-yl((2-(trimethylsilyl)ethoxy)methyl)carbamoyl)-3,4-dihydroisoquinolin-2(1H)-yl)thiazole-4-carboxylateHCID 59447596—
Reactanttert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylateHCID 136027725—
Product1-(2-(4-(Benzyloxy)phenoxy)ethyl)pyrrolidineHCID 803120—

Reaction Steps

Compound 106A was prepared in a similar manner to the synthesis of compound 35A by substituting compound 34D and compound 31F with 2-(pyrrolidin-1-yl)ethanol and 4-(benzyloxy)phenol, respectively: DCI (+)MS: 298 (M+H)+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08232273B2
Source datasetuspto-grants-2012_07
ORD IDord-a02de7f9635b442b8ba82e94715835f3
Source noteuspto-grants-2012_07