HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(2-(4-(Benzyloxy)phenoxy)ethyl)pyrrolidine → 4-[2-(Pyrrolidin-1-yl)ethoxy]phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(2-(4-(Benzyloxy)phenoxy)ethyl)pyrrolidine | HCID 803120 | — |
| Reactant | tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate | HCID 136027725 | — |
| Product | 4-[2-(Pyrrolidin-1-yl)ethoxy]phenol | HCID 13576239 | — |
Reaction Steps
Compound 106B was prepared in a similar manner to the synthesis of compound 31F by substituting compound 31E with compound 106A: 1H NMR (DMSO-d6): δ 8.88 (s, 1H), 6.72-6.75 (m, 2H), 6.64-6.67 (m, 2H), 3.94 (d, J=6.1 Hz, 2H), 2.72 (d, J=5.95 Hz, 2H), 2.48-2.51 (m, 4H), 1.65-1.68 (m, 4H) ESI (+)/MS: 208 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08232273B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-486e5b81052b41f1b89ee42ebffe8f8e |
| Source note | uspto-grants-2012_07 |