Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1518408Generated: November 3, 2026

2-(Dimethylamino)ethanol → 2-(2-chloropyrimidin-5-yloxy)-N,N-dimethylethanamine

https://huagongshe.com/reaction/1518408

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Dimethylamino)ethanolHCID 7902—
Reactant2-Chloro-5-pyrimidinolHCID 14595700—
Reactanttert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylateHCID 136027725—
Product2-(2-chloropyrimidin-5-yloxy)-N,N-dimethylethanamineHCID 59447495—

Reaction Steps

Compound 112B was prepared in a similar manner to the synthesis of step 1 of Example 35 by substituting compound 34D and compound 31F with 2-(dimethylamino)ethanol and compound 112A, respectively: ESI (+)MS: 201 (M+H)−.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08232273B2
Source datasetuspto-grants-2012_07
ORD IDord-a1eb909c926f4edcaf8e0c36d7162c66
Source noteuspto-grants-2012_07