2-(Dimethylamino)ethanol → 2-(3-(benzyloxy)phenoxy)-N,N-dimethylethanamine

HRID 1518411Notes

Reaction equation

HRID 1518411 reaction equation
NC1N(C(OC(C)(C)C)=O)N=C(C2C=CC(O)=CC=2)C=1C#N.[CH3:23][N:24]([CH3:28])[CH2:25][CH2:26][OH:27].[CH2:29]([O:36][C:37]1[CH:38]=[C:39](O)[CH:40]=[CH:41][CH:42]=1)[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1>>[CH2:29]([O:36][C:37]1[CH:42]=[C:41]([CH:40]=[CH:39][CH:38]=1)[O:27][CH2:26][CH2:25][N:24]([CH3:28])[CH3:23])[C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1

Participants

4

Reactant 3

HCID 79022-(Dimethylamino)ethanolHCID 138048Benzyl 3-hydroxyphenyl etherHCID 136027725tert-butyl 5-amino-4-cyano-3-(4-hydroxyphenyl)-1H-pyrazole-1-carboxylate

Product 1

HCID 594475752-(3-(benzyloxy)phenoxy)-N,N-dimethylethanamine

Procedure

Compound 113A was prepared in a similar manner to the synthesis of step 1 of Example 35 by substituting compound 34D and compound 31F with 2-(dimethylamino)ethanol and 3-(benzyloxy)phenol, respectively: DCI (+)MS: 272 (M+H)+.

Sources & evidence

ORD record
ord-e085dc17c5ac429fa2e4f8374ba75308
Source dataset
uspto-grants-2012_07
Patent number
US08232273B2

Reaction notes

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