Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine → Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidine | HCID 4184869 | — |
| 반응물 | 4,6-Dihydroxynicotinonitrile | HCID 54706325 | — |
| 반응물 | 4-(5-chloro-4-hydroxy-2-oxopyridin-1(2H)-yl)-2-fluorobenzonitrile | HCID 67366532 | — |
| 반응물 | 1-(5-Propylpyrimidin-2-yl)piperidin-4-ylmethanesulfonate | HCID 86658030 | — |
| 생성물 | Tert-butyl 4-(5-chloro-1-(4-cyano-3-fluorophenyl)-2-oxo-1,2-dihydropyridin-4-yloxy)piperidine-1-carboxylate | HCID 57468467 | — |
반응 단계
The intermediate was prepared according to the procedures described in Example 221 substituting 4-(5-chloro-4-hydroxy-2-oxopyridin-1(2H)-yl)-2-fluorobenzonitrile for 4-hydroxy-6-oxo-1,6-dihydropyridine-3-carbonitrile and tert-butyl 4-(methylsulfonyloxy)piperidine-1-carboxylate for 1-(5-propylpyrimidin-2-yl)piperidin-4-ylmethanesulfonate in Step B. MS (ESI) 392 (M+H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08232404B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-f67ae656b49c4deaae98e59761787134 |
| 출처 메모 | uspto-grants-2012_07 |