Trifluoroacetic acid → 5-Bromo-3-(5-(2,3-dichlorophenyl)thiazol-4-yl)pyridin-2-amine

HRID 1518532노트

반응식

HRID 1518532 반응식
COC1C=CC(C[NH:8][C:9]2[C:14]([C:15]3[N:16]=[CH:17][S:18][C:19]=3[C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=3[Cl:27])=[CH:13][C:12]([Br:28])=[CH:11][N:10]=2)=CC=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[Br:28][C:12]1[CH:13]=[C:14]([C:15]2[N:16]=[CH:17][S:18][C:19]=2[C:20]2[CH:25]=[CH:24][CH:23]=[C:22]([Cl:26])[C:21]=2[Cl:27])[C:9]([NH2:8])=[N:10][CH:11]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 58179565N-(4-methoxybenzyl)-5-bromo-3-(5-(2,3-dichlorophenyl)thiazol-4-yl)pyridin-2-amine

생성물 1

HCID 581795705-Bromo-3-(5-(2,3-dichlorophenyl)thiazol-4-yl)pyridin-2-amine수율 2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of N-(4-methoxybenzyl)-5-bromo-3-(5-(2,3-dichlorophenyl)thiazol-4-yl)pyridin-2-amine (110 mg) and TFA (100 μL) in methylene chloride (2 mL) was stirred at 40° C. overnight. The reaction was concentrated and purified by reversed-phase HPLC to give 5-bromo-3-(5-(2,3-dichlorophenyl)thiazol-4-yl)pyridin-2-amine as a white solid [1.1 mg, 2% yield; LC-MS M+H=519.9; 1H-NMR (300 MHz, methanol-d4) 9.17 (1H, d), 7.95 (1H, d), 7.60-7.63 (2H, m), 7.34-7.35 (1H, m), 7.27 (1H, dd)].

후처리

  1. concentrationThe reaction was concentrated
  2. custompurified by reversed-phase HPLC

출처 및 근거

ORD 기록
ord-ffb5aca283f94bcb99a743ca4d6c0bc7
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08232406B2

반응 노트

불러오는 중…