反应详情

75.6 g (0.56 mol) of para-tolylisocyanate were placed with 500 ml toluene in a one litre vessel and subsequently 73.4 g (0.51 mol) of 2-isopropylcyclohexanol were added. The reaction mixture was heated to reflux for 6 hours. After cooling to room temperature 50 g of water were added and the mixture was refluxed for one more hour. After phase separation the solvent was stripped off and the crude product recrystallized from 235 g of n-heptane. The product (79.8 g) was obtained in form of off-white crystals in 99.2% purity. This corresponds to a theoretical yield of 56%.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 6 hours
3. additionwere added
4. temperaturethe mixture was refluxed for one more hour
5. customAfter phase separation the solvent
6. customthe crude product recrystallized from 235 g of n-heptane