Nitric Acid → HCID 19989839, compound

HRID 1518621Notes

Reaction equation

HRID 1518621 reaction equation
[Br:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:4][CH:3]=1.[N+:15]([O-])([OH:17])=[O:16]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([CH2:8][CH2:9][C:10]([OH:12])=[O:11])=[O:7])=[CH:13][C:14]=1[N+:15]([O-:17])=[O:16]

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 806463-(4-Bromobenzoyl)propionic acid

Product 1

HCID 19989839HCID 19989839, compound

Conditions

Temperature
-5 °C

Procedure

Under salt-ice cooling, 3-(4-bromobenzoyl)propionic acid (75.0 g, 291.7 mmol) was added to fuming nitric acid (200 mL) in portions at such a rate that the temperature of the reaction solution could be maintained at −5° C. or lower. After stirring at −12° C. to −10° C. for 1 hour, the reaction solution was poured onto ice. The solid which precipitated was collected by filtration, washed with purified water, and thereafter dried under reduced pressure to obtain 3-(4-bromo-3-nitrobenzoyl)propionic acid (91.0 g).

Workup

  1. additionthe reaction solution was poured onto ice
  2. customThe solid which precipitated
  3. filtrationwas collected by filtration
  4. washwashed with purified water
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-7cbf4d8a5c494dd7a268abfcd71562be
Source dataset
uspto-grants-2015_07
Patent number
US09072734B2

Reaction notes

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