Dehydroaripiprazole → HCID 58579177, 화합물

HRID 1518659노트

반응식

HRID 1518659 반응식
[CH2:1]([N:8]([CH2:12][C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:9](Cl)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:19]1[N:24]([CH2:25][CH2:26][CH2:27][CH2:28][O:29][C:30]2[CH:35]=[CH:34][C:33]3[CH:36]=[CH:37][C:38]([NH:40][C:32]=3[CH:31]=2)=[O:39])[CH2:23][CH2:22][N:21]([C:41]2[CH:46]=[CH:45][CH:44]=[C:43]([Cl:47])[C:42]=2[Cl:48])[CH2:20]1>N1C=CC=CC=1>[CH2:12]([N:8]([CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:9](=[O:10])[O:39][C:38]1[CH:37]=[CH:36][C:33]2[C:32](=[CH:31][C:30]([O:29][CH2:28][CH2:27][CH2:26][CH2:25][N:24]3[CH2:23][CH2:22][N:21]([C:41]4[CH:46]=[CH:45][CH:44]=[C:43]([Cl:47])[C:42]=4[Cl:48])[CH2:20][CH2:19]3)=[CH:35][CH:34]=2)[N:40]=1)[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

4

반응물 2

HCID 10114519DehydroaripiprazoleHCID 12712012Dibenzylcarbamyl chloride

생성물 1

HCID 58579177HCID 58579177, 화합물

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added dehydro-aripiprazole (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound-342 (0.71 g) as a white solid.

후처리

  1. temperaturethe reaction mixture heated
  2. temperatureat reflux for 4 h
  3. concentrationThe reaction mixture was concentrated
  4. dissolutionThe residue was dissolved in ethyl acetate (ethyl acetate)
  5. washwashed with water
  6. dry with materialdried over MgSO4
  7. customAfter evaporation the residue
  8. customwas further purified on silica eluting with ethyl acetate
  9. customafter drying
  10. customgave Compound-342 (0.71 g) as a white solid

출처 및 근거

ORD 기록
ord-507af16bc76c47af83f364881c841c8b
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09072788B2

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