反应详情

To a solution of dibenzylcarbamoyl chloride (1.7 g, 6.7 mmol) in pyridine (15 mL) was added dehydro-aripiprazole (1.5 g, 3.4 mmol) and the reaction mixture heated at reflux for 4 h. The reaction mixture was concentrated and the residue co-evaporated with toluene (×3). The residue was dissolved in ethyl acetate (ethyl acetate), washed with water and dried over MgSO4. After evaporation the residue was further purified on silica eluting with ethyl acetate and after drying gave Compound-342 (0.71 g) as a white solid.

1. temperaturethe reaction mixture heated
2. temperatureat reflux for 4 h
3. concentrationThe reaction mixture was concentrated
4. dissolutionThe residue was dissolved in ethyl acetate (ethyl acetate)
5. washwashed with water
6. dry with materialdried over MgSO4
7. customAfter evaporation the residue
8. customwas further purified on silica eluting with ethyl acetate
9. customafter drying
10. customgave Compound-342 (0.71 g) as a white solid