Pyridine → HCID 56596935, 화합물

HRID 1518662노트

반응식

HRID 1518662 반응식
[CH2:1]1[N:6]([CH2:7][CH2:8][CH2:9][CH2:10][O:11][C:12]2[CH:17]=[CH:16][C:15]3[CH:18]=[CH:19][C:20]([NH:22][C:14]=3[CH:13]=2)=[O:21])[CH2:5][CH2:4][N:3]([C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=2[Cl:30])[CH2:2]1.N1C=CC=CC=1.[C:37](Cl)(=[O:42])[C:38]([CH3:41])([CH3:40])[CH3:39]>ClCCl>[C:37]([O:21][C:20]1[CH:19]=[CH:18][C:15]2[C:14](=[CH:13][C:12]([O:11][CH2:10][CH2:9][CH2:8][CH2:7][N:6]3[CH2:5][CH2:4][N:3]([C:23]4[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[C:24]=4[Cl:30])[CH2:2][CH2:1]3)=[CH:17][CH:16]=2)[N:22]=1)(=[O:42])[C:38]([CH3:41])([CH3:40])[CH3:39]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 62493Pivaloyl chlorideHCID 10114519Dehydroaripiprazole

생성물 1

HCID 56596935HCID 56596935, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of dehydro-aripiprazole (1.2 g, 2.7 mmol) in dichloromethane (30 mL) was added pyridine (1 mL), followed by pivaloyl chloride (0.66 mL, 5.4 mmol). The reaction mixture was stirred for 20 hours, then washed with water and dried over MgSO4. After evaporation the residue was co-evaporated with toluene and then further purified on silica eluting with ethyl acetate. After evaporation of the product containing fraction, Compound-316 (0.53 g) was obtained as a colourless oil.

후처리

  1. washwashed with water
  2. dry with materialdried over MgSO4
  3. customAfter evaporation the residue
  4. customfurther purified on silica eluting with ethyl acetate
  5. customAfter evaporation of the product
  6. additioncontaining fraction
  7. customCompound-316 (0.53 g) was obtained as a colourless oil

출처 및 근거

ORD 기록
ord-35828f4ceb1d43778f2eccd456761685
출처 데이터셋
uspto-grants-2015_07
특허 번호
US09072788B2

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