Sodium borohydride → HCID 86718360, compound

Participants

Reaction Steps

To a solution of compound 2.7a (0.95 g, 2.78 mmol) in methanol (7 mL) was added sodium borohydride (1.05 g, 27.8 mmol, 10.0 equiv) at 0° C. After stirring for 1 hour, the reaction was quenched with 1.0 M sulfuric acid and extracted with DCM. Combined organic layer was dried with anhydrous sodium sulfate, filtered and concentrated in vacuo to give compound 2.8.1a (0.85 g) which was used for the next step without further purification. MS m/z (M+Na) 336.3

Provenance & Evidence