HCID 86718365, compound → HCID 86718366, compound

Participants

Reaction Steps

To a solution of 2.12c (360 mg, 1.07 mmol) in ethyl acetate (5 mL) was added Pd/C (5% on charcoal, 114 mg, 0.107 mmol) and the resulting mixture was stirred under 1 atm of H2 for 1 hour. The solid was then removed by filtration and the filtrate was concentrated in vacuo to afford 2.12d (360 mg) which was used in the next step without further purification. MS m/z (M+23) 362.3. 1H NMR (400 MHz, CDCl3) δ ppm 0.91-0.97 (m, 3H) 1.24 (t, J=7.16 Hz, 3H) 1.36-1.47 (m, 7H) 1.47-1.52 (m, 5H) 1.52-1.57 (m, 4H) 2.66 (s, 3H) 4.10 (d, J=7.24 Hz, 2H) 6.31 (d, J=1.91 Hz, 2H) 6.32 (s, 1H) 7.26 (s, 3H) 7.35 (ddd, J=1.23, 0.78, 0.67 Hz, 1H).

Provenance & Evidence