HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
4-Chloro-3-nitrobenzenesulfonamide → 4-(4-Methylpiperazin-1-ylamino)-3-nitrobenzenesulfonamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| Edukt | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Edukt | 4-Methylpiperazin-1-ylamine dihydrochloride hydrate | HCID 198221 | — |
| Lösungsmittel | 1,4-Dioxane | HCID 31275 | — |
| Produkt | 4-(4-Methylpiperazin-1-ylamino)-3-nitrobenzenesulfonamide | HCID 4737741 | — |
Reaktionsschritte
A mixture of 4-chloro-3-nitrobenzenesulfonamide (1 g), 4-methylpiperazin-1-amine dihydrochloride (1 g) and N,N,N2,N2-tetramethylethane-1,2-diamine (3 mL) in dioxane (10 mL) was refluxed for 12 hours, cooled to ambient temperature and filtered. The filtrate was added to a silica gel column (Analogix, SF65-200 g) and purified by eluting with 1-5% methanol/dichloromethane).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09072748B2 |
| Quelldatensatz | uspto-grants-2015_07 |
| ORD ID | ord-c7f0a6f6585a4bdcb5b07b50ccce1662 |
| Quellennotiz | uspto-grants-2015_07 |