Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Azobisisobutyronitrile → 5-(Bromomethyl)-4-(4-chlorophenyl)-2-fluoropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Azobisisobutyronitrile | HCID 6547 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 4-(4-Chlorophenyl)-2-fluoro-5-methylpyridine | HCID 67225918 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 생성물 | 5-(Bromomethyl)-4-(4-chlorophenyl)-2-fluoropyridine | HCID 67227341 | — |
반응 단계
A mixture of EXAMPLE 307A (1.2 g), N-bromosuccinimide (1.06 g) and AIBN (azobisisobutyronitrile) (0.178 g) in CCl4 (30 mL) was heated under reflux for 6 hours. After cooling, the solid was filtered off. The filtrate was concentrated and loaded onto a silica gel column eluting with 3% ethyl acetate in hexanes to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09072748B2 |
| 출처 데이터셋 | uspto-grants-2015_07 |
| ORD ID | ord-5cc2694fe2fb4542b0c48261b415969c |
| 출처 메모 | uspto-grants-2015_07 |