Morpholine → 4-Morpholinobut-2-YN-1-OL

HRID 1518858Notes

Reaction equation

HRID 1518858 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl[CH2:8][C:9]#[C:10][CH2:11][OH:12]>C1(C)C=CC=CC=1>[O:4]1[CH2:5][CH2:6][N:1]([CH2:8][C:9]#[C:10][CH2:11][OH:12])[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 2027752-Butyn-1-ol, 4-chloro-

Product 1

HCID 31128494-Morpholinobut-2-YN-1-OL

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Conditions

Temperature
85 °C

Procedure

To a mixture of morpholine (4.36 g) in toluene (15 mL) was added 4-chlorobut-2-yn-1-ol (2.09 g) in toluene (5 mL). The mixture was stirred at 85° C. for three hours. After cooling, the solid was filtered off. The filtrate was subjected to vacuum distillation to give the title compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe solid was filtered off
  3. distillationThe filtrate was subjected to vacuum distillation

Sources & evidence

ORD record
ord-e526745dacae4ab4bcc5552495d4d559
Source dataset
uspto-grants-2015_07
Patent number
US09072748B2

Reaction notes

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