Pyridine → HCID 118202506, compound

HRID 1518910Notes

Reaction equation

HRID 1518910 reaction equation
N[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:4].[C:11]([O:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](Cl)(=[O:26])=[O:25])=[CH:20][CH:19]=1)(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13].[N:28]1C=CC=CC=1>>[C:11]([O:17][C:18]1[CH:23]=[CH:22][C:21]([S:24](=[O:26])(=[O:25])[NH:28][C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[C:3](=[O:4])[CH3:2])=[CH:20][CH:19]=1)(=[O:16])[C:12]([CH3:15])([CH3:14])[CH3:13]

Participants

4

Reactant 3

HCID 1049Pyridine2×HCID 11952PhenacylamineHCID 110112774-(Chlorosulfonyl)phenyl 2,2-dimethylpropanoate

Product 1

HCID 118202506HCID 118202506, compoundYield 89%

Procedure

2-Aminoacetophenone (1 mmol) and p-pivaloyloxybenzenesulfonyl chloride (1.5 equivalent weights) were added into pyridine (5 mL) to obtain a mixture, followed by subjecting to reaction at room temperature for 4 hours and then removing pyridine under vacuum to obtain a reaction product. The reaction product was purified using a silica gel column (n-hexane/acetone=4:1), thereby obtaining 4-(N-(2-acetylphenyl)sulfamoyl)phenyl pivalate (331 mg, yield 89%).

Workup

  1. customto obtain a mixture
  2. customby subjecting to reaction at room temperature for 4 hours
  3. customThe reaction product was purified

Sources & evidence

ORD record
ord-1afe233fdc184eff8702ef3b64aa06c9
Source dataset
uspto-grants-2015_07
Patent number
US09073833B1

Reaction notes

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