反应详情

Add Pd/C (5 wt/wt %, 0.26 g, 0.12 mmol) to a solution of tert-butyl 4-(6-(benzyloxy)pyridin-2-yl)-5,6-dihydropyridine-1(2H)-carboxylate (2.6 g; 7.1 mmol) in methanol (20 mL) add Pd/C (5 wt/wt %, 0.26 g, 0.12 mmol) and stir overnight under a hydrogen balloon. Filter and concentrate under vacuum to give the crude product. Purify with normal phase silica gel flash column chromatography, using a gradient of 0-20% MeOH in DCM to give the title product as a white solid (1.2 g, 615). MS (m/z): 223 (M-t-Bu+1).

1. filtrationFilter
2. concentrationconcentrate under vacuum
3. customto give the crude product
4. customPurify with normal phase silica gel flash column chromatography