HCID 89713636, compound → HCID 117737778, compound

Participants

Reaction Steps

Add sodium tetraborohydride (535.9 mg, 14.2 mmol) to a solution of tert-butyl 4-oxo-3-(thiazol-2-yl)piperidine-1-carboxylate (4.0 g, 14.2 mmol) in MeOH (175 mL) and stir at ambient temperature for 45 minutes. Quench the reaction mixture with water (100 mL). Concentrate under vacuum to remove MeOH. Extract the aqueous residue with EtOAc (3×100 mL), combine the organic extracts and sequentially wash with water (100 mL) then brine (100 mL). Dry over sodium sulphate; filter; collect the filtrate; and concentrate under vacuum to give the title compound as a mixture of diastereomer pairs (3.9 g). MS (m/z): 285 (M+1).

Provenance & Evidence