反应详情

温度

-15 °C

To a solution of compound 7B (700 mg, 3.9 mmol) in CH2Cl2 (15 mL) was added PBr3 (5.8 mL, 5.8 mmol, 1N in CH2Cl2) at −15° C., and stirred at −15° C. for 3 hr. The reaction was slowly quenched with saturated NaHCO3 solution at −15° C. The organic layer was separated, dried over MgSO4, and concentrated. Purification by silica gel chromatography (0-10% EtOAc in hexanes) provide the title compound (270 mg) as a white powder.

1. customThe reaction was slowly quenched with saturated NaHCO3 solution at −15° C
2. customThe organic layer was separated
3. dry with materialdried over MgSO4
4. concentrationconcentrated
5. customPurification by silica gel chromatography (0-10% EtOAc in hexanes)