Methanol → Methyl 2-aminoisobutyrate hydrochloride

Participants

Reaction Steps

A 100-mL flask was charged with 2-amino-2-methylpropionic acid (3.0 g, 29.1 mmol) and methanol (45 ml). An ice bath was set, and thionyl chloride (4.25 ml, 58.2 mmol) was slowly added thereto. After the addition was completed, the ice bath was removed. At room temperature, the mixture was stirred for 3 hours. The resultant product was vacuum-distilled to remove a solvent, and then added with ethyl ether (30 ml), stirred at room temperature for 30 minutes, and filtered. The solid obtained through filtering was dried in a 60° C. oven to obtain methyl-2-amino-2-methylpropanoate hydrochloride (4.2 g, 94%).

Provenance & Evidence