Water → Methyl-1-(2-nitrophenylsulfonamido)cyclobutanecarboxylate

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Reaction Steps

methyl-1-aminocyclobutanecarboxylate hydrochloride (300 mg, 1.81 mmol) was dissolved in CH2Cl2 (7 ml), added with 2-nitrobenzene-1-sulfonyl chloride (441 mg, 1.99 mmol) and triethylamine (1 ml, 7.24 mmol) and stirred at room temperature for 12 hours. The resultant solution was added with H2O, extracted with CH2Cl2 (×2), dried with MgSO4, and filtered. Through vacuum distillation, the solvent was removed. The resultant mixture was purified with column chromatography so as to obtain methyl-1-(2-nitrophenylsulfonamido)cyclobutanecarboxylate (512 mg, 1.63 mmol, 90%).

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