Methanol → Methyl 1-aminocyclohexane-1-carboxylate hydrochloride

Participants

Reaction Conditions

Reaction Steps

A 100-mL flask was charged with 1-amino-cyclohexanecarboxylic acid (3.0 g, 20.9 mmol) and methanol (50 mL). The mixture was cooled to 0-5° C. by ice bath and thionyl chloride (7.6 mL, 104 mmol) was slowly added thereto. After the addition was completed, the ice bath was removed. At room temperature, the mixture was stirred for 2 days. The resultant product was vacuum-distilled to remove a solvent, and then added with ethyl ether (50 ml), stirred at room temperature for 30 minutes, and filtered. The solid obtained through filtering was dried in a 60° C. oven to obtain 1-amino-cyclohexanecarboxylic acid methylester hydrochloride (3.2 g, 79%).

Provenance & Evidence