Water → HCID 71246507, compound

Participants

Reaction Steps

methyl-2-methyl-2-(quinoline-8-sulfonamido)propanoate (699 mg, 2.26 mmol) was dissolved in DMF (10 ml), added with MeI (0.49 ml, 7.93 mmol) at 0° C., and stirred at room temperature for 12 hours. The resultant solution was added with H2O and extracted with EA (×2). The organic solution was washed with H2O, dried with MgSO4, and filtered. Through vacuum distillation, the solvent was removed. The resultant mixture was purified with column chromatography so as to obtain methyl-2-methyl-2-(N-methylquinoline-8-sulfonamido)propanoate (694 mg, 2.15 mmol, 95%).

Provenance & Evidence