Methanol → Methyl 2-aminoisobutyrate hydrochloride

Participants

Reaction Steps

2-amino-2-methylpropionic acid (10 g, 96.9 mmol) and methanol (330 ml) were charged. An ice bath was set and thionyl chloride (17.68 ml, 242.25 mmol) was slowly added thereto. Then, the ice bath was removed, and the mixture was stirred at room temperature for 3 hours. The resultant product was vacuum-distilled to remove a solvent, and dried in a 60° C. oven so as to obtain methyl-2-amino-2-methylpropanoate hydrochloride (14.59 g, 94.9 mmol, 98%).

Provenance & Evidence