HCID 71246520, compound → HCID 86727919, compound

Participants

Reaction Steps

Ina 25-mL flask, 4-[2-(2-nitro-benzenesulfonylamino)-2-methyl-propionylamino]-adamantane-1-carboxylic acid amide (30 mg, 0.0645 mmol) and methanol (5 mL) were charged and dissolved, and 5% Pd/c (10 mg) was added thereto. The reaction vessel was degassed under reduced pressure, and filled with hydrogen. At room temperature, through stirring for 3 hours, the reaction was completed. Then, through celite filtering, Pd was removed. At 35° C., through vacuum evaporation, 4-[2-(2-amino-benzenesulfonylamino)-2-methyl-propionylamino]-adamantane-1-carboxylic acid amide (21 mg, 75.0%) was obtained.

Provenance & Evidence