HCID 90310583, compound → HCID 90310750, compound

HRID 1519173Notes

Reaction equation

HRID 1519173 reaction equation
[C:1]([Si:5]([O:8][C:9]1[C:14]([CH3:15])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2].F[C:18]1C=CC=C(C=C)C=1O>>[C:1]([Si:5]([O:8][C:9]1[C:14]([CH:15]=[CH2:18])=[CH:13][CH:12]=[CH:11][C:10]=1[F:16])([CH3:7])[CH3:6])([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 90310583HCID 90310583, compoundHCID 90310586HCID 90310586, compound

Product 1

HCID 90310750HCID 90310750, compound

Procedure

The title compound was prepared in an analogous way to tert-butyl(2-fluoro-6-methylphenoxy)dimethylsilane in Step A of Intermediate J using 2-fluoro-6-vinylphenol. 1H NMR (500 MHz, CDCl3) δ 7.26 (m, 1H), 7.03 (dd, J=17.8, 11.1, 1H), 6.96 (m, 1H), 6.89-6.81 (m, 1H), 5.68 (dd, J=17.8, 1.3, 1H), 5.34-5.24 (m, 1H), 1.02 (s, 9H), 0.19 (d, J=2.4, 6H).

Sources & evidence

ORD record
ord-780954c506ca4a63bf7c626058d922bb
Source dataset
uspto-grants-2015_07
Patent number
US09073876B2

Reaction notes

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