HCID 90310844, compound → HCID 90310579, compound

HRID 1519175Notes

Reaction equation

HRID 1519175 reaction equation
[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:8]2[C:9]([F:16])=[C:10]([OH:15])[C:11]([CH3:14])=[CH:12][CH:13]=2)=[N:6][CH:7]=1.[C:17]([Si](OC1C(F)=CC=CC=1CC)(C)C)(C)(C)C>>[NH2:1][C:2]1[N:3]=[CH:4][C:5]([C:8]2[C:9]([F:16])=[C:10]([OH:15])[C:11]([CH2:14][CH3:17])=[CH:12][CH:13]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 90310844HCID 90310844, compoundHCID 90310848HCID 90310848, compound

Product 1

HCID 90310579HCID 90310579, compound

Procedure

The title compound was prepared in an analogous way to 3-(5-aminopyrazin-2-yl)-2-fluoro-6-methylphenol in Steps B-D of Intermediate J using tert-butyl(2-ethyl-6-fluorophenoxy)dimethylsilane. 1H NMR (500 MHz, CD3OD) δ 8.26 (dd, J=2.3, 1.5, 1H), 8.02 (d, J=1.5, 1H), 7.12 (dd, J=8.0, 7.3, 1H), 6.99-6.93 (m, 1H), 2.68 (q, J=7.5, 2H), 1.21 (t, J=7.5, 3H).

Sources & evidence

ORD record
ord-501d8ee0cadd4236a5f00ca7f11b7c65
Source dataset
uspto-grants-2015_07
Patent number
US09073876B2

Reaction notes

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