2-Bromo-1-[4-(trifluoromethoxy)phenyl]ethan-1-one → 2'-Nitro-4-[4-(4-trifluoromethoxy-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid

関与物質

反応手順

2′-Nitro-4-[4-(4-trifluoromethoxy-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid (190 mg, 62%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 4-(trifluoromethoxy)phenacyl bromide (available from Matrix Scientific) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 13.17 (s, 1H), 8.58 (d, J=2.0 Hz, 1H), 8.13-8.28 (m, 4H), 7.63-7.82 (m, 2H), 7.41-7.51 (m, 4H).

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