2-Bromo-4'-(trifluoromethyl)acetophenone → 2'-Nitro-4-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid

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2′-Nitro-4-[4-(4-trifluoromethyl-phenyl)-thiazol-2-yl]-biphenyl-2-carboxylic acid (120 mg, 40%) was prepared from 2′-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester (which may be prepared as described for Intermediate 4) and 4-(trifluoromethyl)phenacyl bromide (available from Oakwood Products, Inc.) using the procedure described for the preparation of Example 1. 1H NMR (300 MHz, DMSO-d6) δ 13.16 (s, 1H), 8.59 (s, 1H), 8.51 (s, 1H), 8.27-8.31 (m, 3H), 8.15 (d, J=8.1 Hz, 1H), 7.77-7.87 (m, 3H), 7.66 (t, J=8.0 Hz, 1H), 7.42-7.49 (m, 2H).

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